Charles Fleischer

Roger Rabbit (voice)

Kathleen Turner

Jessica Rabbit (voice)

April Winchell

Young Baby Herman / Mrs. Herman (voice)

Lou Hirsch

Adult Baby Herman (voice)

Corey Burton

Droopy Dog (voice)

Frank Welker

Bull (voice)

Damian London

Fritz

Joni Barnes

Secretary

Jimmy Bracken

Cameraman

Angel Cook

Fireman